Final year Presentation of MSc and B. Tech students

We are absolutely thrilled to celebrate the remarkable research achievements of our exceptionally talented students from the Therapeutic Design and Discovery Lab. These students have recently showcased their project work with exceptional clarity, scientific depth, and an impressive level of professionalism that has truly set a high standard. Their presentations not only highlighted their individual research endeavors but also reflected a collective commitment to advancing scientific knowledge and addressing pressing global health challenges:

• Khadija Mithaiwala (M.Sc.) Presented on: "Identification of a Potential Drug Candidate for Targeting Plasmodium falciparum NCR1 for Malaria". In her groundbreaking research, Khadija delves into innovative avenues for antimalarial drug discovery, specifically targeting the Plasmodium falciparum NCR1 protein. Her work is of paramount importance as it contributes significantly to the global fight against malaria, a disease that continues to pose a substantial threat to public health in many regions. By identifying and characterizing potential drug candidates, her research aims to pave the way for the development of more effective treatments that could ultimately save countless lives.

• Lakshika Chaudhary (M.Sc.) Presented on: "In silico Discovery of Amentoflavone as a LolCDE Inhibitor with Microbiome-Sparing Potential". Lakshika's findings provide promising insights into the realm of targeted antibacterial strategies, particularly through her exploration of Amentoflavone as a potential inhibitor of the LolCDE system. What makes her research particularly noteworthy is its focus on preserving the beneficial microbiome while effectively combating bacterial infections. This innovative approach holds great promise for the development of future antibiotics that can minimize disruption to the body's natural flora, thereby enhancing patient outcomes and fostering a more sustainable approach to antibiotic therapy.

• Aviha Rajesh Joshi and Srushti Shinde (B.Tech – Bioengineering) Presented on: "Investigating CAZ-Avi Resistance in KPC-2 and Its Variants". Their collaborative study tackles the critical challenges posed by antibiotic resistance, particularly focusing on the KPC-2 enzyme and its variants. By investigating the mechanisms of resistance, Aviha and Srushti aim to uncover vital insights that could inform the design of more effective therapeutic responses against resistant bacterial strains. Their work is particularly timely and relevant, given the increasing prevalence of antibiotic resistance, which poses a significant threat to global health. Their dedication to this pressing issue reflects a commitment to improving patient care and advancing the field of bioengineering.

We extend our heartfelt congratulations to all of these outstanding students for their successful presentations and the unwavering dedication they have demonstrated throughout their research endeavors. Their hard work and innovative thinking not only contribute to their personal academic growth but also to the broader scientific community. We wish them the very best in their academic and research journeys ahead, as they continue to explore new frontiers in therapeutic design and discovery.