Understanding of SARS-CoV-2’s Immune Evasion

"Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?" in ACS Pharmacology & Translational Science (Impact Factor: 5.1). Recent findings in a Nature journal have shown that the spike protein of SARS-CoV-2 binds with fibrinogen, leading to thrombo inflammation. This raises a fundamental question: Why does the virus need to bind with fibrinogen? Could this interaction provide an evolutionary advantage? Could this be the reason behind post covid heart attack cases? In our latest viewpoint, we explore the potential evolutionary benefits of this interaction and present supporting evidence for how SARS-CoV-2 may exploit fibrinogen to evade immune responses.

DYPIU congratulates Dr. Shashi Singh and Dr. Parth Sarthi Sen Gupta on their impactful research publication in ACS Pharmacology & Translational Science. Their work significantly advances our understanding of SARS-CoV-2’s immune evasion.